Pintu Kumar Mandal, Ph.D.
Principle Scientist,Division Of Medicinal and Process Chemistry
Complex biologically relevant oligosaccharides
and glycoconjugates synthesis
Glyco-conjugates are the most functionally and structurally diverse molecules in nature and it is now well established that protein- and lipid-bound saccharides play essential roles in many molecular processes impacting eukaryotic biology and disease. Our group is addressing these issues by developing efficient methods and strategies for complex biologically relevant oligosaccharides that can be utilized for designing glyco-conjugates and vaccine designing.
In particular, we have developed methods that employ a small number of monosaccharide building blocks for the assembly of the large number of complex compounds through minimal number of chemical steps.
Furthermore, we have devised new approaches for controlling anomeric selectivity for stereoselective glycosylation, which represent one of the most important stumbling blocks in oligosaccharide assembly. The group is also engaged in the design and synthesis of medicinally active heterocyclic scaffolds and pharmacophores.
▶ Cooperative catalyzed stereoselective glycosidation
▶ Complex biologically relevant oligosaccharides and glycoconjugates synthesis.
▶ Synthesis of Biologically Significant functionalized carbohydrate structures
▶ Developing glycoside bond formation methodologies and new approaches for controlling anomeric selectivity
▶ Design and synthesis of medicinally active heterocyclic scaffolds and pharmacophores.
▶ Natural products and steroidal oligoglycosides.
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