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हिंदी वेबसाइट

PCR based diagnostic probe for tuberculosis A novel DNA fragment of M. tuberculosis useful in early diagnosis of tuberculosis coupled with PCR technology has been developed. Laboratory process know-how for the preparation of specific DNA probes and oligonucleotide primers were developed and licensed to Biotron Health Care Ltd., Mumbai for commercialization.
PCR-based diagnostic probe for leishmaniasis probe for early detection of visceral leishmaniasis has been developed by using a pair of oligonucleotide primers constructed from predominant sequence class of kinetoplast DNA minicircle of Leishmania donovani. Indian patent has been filed for the technology.	Direct agglutination test (DAT) for leishmaniasis A sensitive, specific (98%) and inexpensive assay for diagnosis of visceral leishmaniasis has been developed and validated in sera of over 3,000 human subjects from endemic and non-endemic areas and can be performed on very small quantities of blood. This is the first global introduction of a simple and reliable test developed for the early diagnosis of kala-azar. The application potential of DAT test has been increased with the preparation of freeze-dried antigen.
LDH-based diagnosis of malaria This comprises an immunodot enzyme staining test, employing anti-LDH polyclonal antibodies for the diagnosis of malaria. The test is highly specific.	PCR based diagnostic probe for tuberculosis A novel DNA fragment of M. tuberculosis useful in early diagnosis of tuberculosis coupled with PCR technology has been developed. Indian patent has been filed.
Lipoprotein A potential marker of coronary heart disease and atherosclerosis clinical significance of serum lipoprotein Lp(a), a cholesterol rich protein, in determining degree of risk of coronary heart disease (CHD) has been established. Serum Lp(a) concentration of 10mg/dl or more has been demonstrated as a potential risk marker in the Indian population. The assay will be a potential risk marker in the Indian population. The assay will be useful in the diagnosis of human subjects at a higher risk of CHD.	Cholera Vaccine The role of plasmid in the regulation of toxin biosynthesis, virulence factors, novel adhesive and colonisation factors of Vibrio cholerae have been demonstrated. A new subunit vaccine based on these colonisation antigens is being developed. An anti-leprosy vaccine developed using Mycobacterium habana antigen could not be taken to phase II and III trials because other two anti-leprosy vaccines developed in the country were showing equally promising protection. The same strain of M. habana is being evaluated as anti-TB vaccine, as an alternative to BCG.