Reproductive Health

Vision and Goal:

• Investigation of the core mechanisms underlying spermatogenesis, oogenesis, and reproduction

• Dissecting reproductive diseases biology, including male infertility, female infertility (PCOS and POF), endometriosis, and benign prostatic hyperplasia (BPH).

• Development of new candidate/ drugs (synthetic and natural) for betterment of reproductive health with particular emphasis on treatment of male and female infertility, endometriosis, and BPH.

• Establishment of new reproductive disease models (in vivo and in vitro) to facilitate understanding of the core processes in reproduction and drug development in reproductive biology.

*Area coordinator

# Coordinator for Biological Screening program

Spermatogenesis and male infertility

• Male infertility mouse model for investigating the mechanisms underlying infertility and screening of potential pro-fertility agents.

• Elutriation facility for purifying testicular germ cells on the basis of size.

• State of the art genomics facility to undertake genomics experiments, including transcriptome, small RNA, DNA and epigenome sequencing.

• GC1, GC2 and TM4 cell lines to study spermatogenesis and male fertility.

• Collaborations with IVF clinics to facilitate research on human male infertility.

Female fertility and infertility

• PCOS mouse model for investigating the mechanisms underlying the pathogenesis and evaluating pro-fertility agents.

• POF mouse model for studying the pathophysiology of POF and evaluating pro-fertility agents.

• Mouse model of endometriosis to study the mechanisms underlying this reproductive ailment.

• Rajesh’s cell lines.

Chemistry

• Design and synthesis of novel molecules for better reproductive health.

• Isolation and purification of natural compounds and identification of pro-fertility and/or anti-fertility activities.

• Reproductive toxicity studies for natural or synthetic compounds.