Dr. Radha Rangarajan

Development of new drugs/drug combinations as therapeutic intervention for malaria, leishmanial and filariasis

Identification of unique targets and pathways for future interventions

Investigations on parasite biology and host-parasite interactions.

Development of novel agents for fracture healing and management of osteoporosis through modern drug design, scientific validation of traditional remedies and generation of new knowledge

The World Health Organization(WHO) has defined Antimicrobial resistance (AMR) as the ability of a microorganism to stop an antimicrobial from working against it. As a result, standard treatments become ineffective, infections persist and may spread to others. It has further stated “AMR is of particular concern in developing nations, including India, where the burden of infectious disease is high and healthcare spending is low. The country has among the highest bacterial disease burden in the world. Antibiotics, therefore, have a critical role in limiting morbidity and mortality in the country.

As per the estimates in the WHO non communicable disease (NCD) Country Profile 2014, Cardio- vascular disease (CVD) is the leading cause of Deaths in India and accounts for 26% of all deaths. As per WHO more than 4% of Indian population (3rd in world after USA and China) is obese, which is the main reason of major CVDs. In 2008, WHO declared dementia/AD as a priority condition through the Mental Health Gap Action Programs

Development of novel therapeutic agents for CVS, CNS and related disorders, cancer, fertility regulation (male/female) and management of endocrine disorders through modern drug design, scientific validation of traditional remedies

Meiosis is the defining event of spermatogenesis. Spermatocytes undergo meiosis to give rise to round spermatids, which in turn metamorphose to flagellated spermatozoa that mature in the epididymis. To characterize the dynamics of gene expression during these important stages of spermatogenesis, undertook transcriptome analysis in >90% pure pachytene spermatocytes and round spermatids, and pure mature sperm of rat by massive parallel deep sequencing.

Discovery and Development of New Avenues for Cancer Therapy and Diagnosis Making Cancer Care Affordable in India

Pre-clinical and clinical development of drug substances and drug products for diseases of national importance, international relevance and public health needs

Continued engagement with drug regulation and pharmaceutical policy making in India as well as internationally