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Microbial Infections

Our research interest is to understand how microbial infections work and to develop new treatments to combat drug-resistant microbes.

Area Co-Ordinators

Bhupendra N Singh

Gautam Panda

Sidharth Chopra

Goals

  • Novel therapeutic interventions for infections caused by mycobacteria, fungi, and ESKAPE pathogens.
  • Murine infection model for persistence and reactivation.
  • Target-based screening systems for antimycobacterial drugs.
  • Recombinant bacterial strains to explore disease pathogenesis.
  • India-specific disease epidemiology and susceptibility studies.

Core Competencies and Activities

  • Cell based screening using a panel of mycobacterial strains with MGIT/BACTEC system.
  • In vitro inhibitor screens for anti-fungal activities and against ESKAPE pathogens.
  • In vivo pre-clinical assays including time kill analysis.
  • Target-based recombinant strains for FAS-II pathway-specific screening.
  • Knock-down strains for screening inhibitors against selective metabolic pathways.
  • Structural and computational biology approaches for rationale-driven discovery

Team Members

  • Amit Misra
  • Jimut K Ghosh
  • Manju Y Krishnan
  • Ashish Arora
  • R Ravishankar
  • Prabhat R Mishra
  • Mohammad I Siddiqi
  • Arunava Dasgupta
  • Mukesh Pasupuleti
  • Ajay K Srivastava
  • Chandra B Tripathi
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