Infectious diseases are now on the list of significant humankind threats. Antibiotic therapies and vaccines have served as the cornerstone in the battle against infectious
diseases over the past century. Currently, this success is being threatened due to the emergence of antibiotic resistance in the pathogens at an alarming rate. Unfortunately,
most of the vaccines currently under use are of no significant importance, due to the emergence of the new strains/variants. The development of new antimicrobial compounds
is not so rapid or near to the rate at which the microbes are developing the resistance against the antimicrobial agent. This gap is alarming the researchers worldwide.
As the problem lies not in the drugs, but the treatment Principal, there is an urgent need for a new class of molecules which can act on the various defensive mechanisms
employed by the microbes to protect themselves.
Biotherapeutics or biologics is an upcoming field in the area of drug discovery and disease management. A look at the recently approved drugs shows that half of them belong to biotherapeutics class.
We focus our attention on the innovation and development of Biotherapeutics, which have the potential to become anti-infective drugs and circumvent the ability of pathogens to
defend themselves from the immune system.
We, not only design and develop novel Biotherapeutics, but also assess the potential of Nanoparticles/Small molecules designed and synthesized by our collaborators for potential anti-infective agents. We, during our screening, also evaluate the potential of molecules to inhibit the bacterial defense mechanism like quorum sensing, biofilm formation, which plays a crucial role in the pathogenesis.
Glimpse of various areas where we work extensively
For the latest data look at our recent publications section
Our group long term interest is to develop new biopharmaceutical based drugs with anti-infective activity, enhanced immunomodulatory and/or anti-inflammatory activities
by using structure activity relationships studies, in order to use them in a broad-range of medical applications. Our scientific career interest is to develop a molecule(s)
that has the potential to shift the balance of inflammation by promoting anti-infective immune mechanisms and suppressing harmful inflammation.
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