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Research Interests

image01 Genetic and epigenetic bases of solid tumor heterogeneity, Cancer Stem Cell (CSC) plasticity and regulation of their key features
image01 Understand the promiscuity and redundancy of Chemokine Receptor Signaling in cancer
image01 In-vitro anticancer screening of synthetic molecules and natural products in 30 solid tumor cell lines and validation in in-vivo xenograft and allograft tumor models

Selected Recent Publications:

image01 Maheshwari S, Avula SR, Datta D* et al. Discovery of a Novel Small-Molecule Inhibitor that Targets PP2A-β-Catenin Signaling and Restricts Tumor Growth and Metastasis. Mol Cancer Ther. 2017 (AACR), 16(9):1791-1805. PMID: 28500231. (JIF-5.76)

image01 Singh AK, Chauhan SS, Datta D* et al. Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer. Carcinogenesis. 2016 Nov 1;37(11):1027-1040. PMID: 27543608. (Editor’s Choice Article) (JIF-5.1)

image01 Arya RK, Singh A, Datta D* et al. Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis.Sci Rep. 2015 Dec 17; 5:18457. (JIF: 5.6)

image01 Singh AK, Arya RK, Datta D* et al. Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance. Int J Cancer. 2015; 136(9):1991-2000. (JIF: 6.5)

image01 Singh AK, Arya RK, Datta D* et al. Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. Cytokine Growth Factor Rev. 2013 Feb; 24(1):41-9. (JIF: 7.96) (Highly Cited Research Award)