CSIR-CDRI offers screening of compounds and selected extracts for companies, startups and other Institutes against selected SARS-CoV-2 targets on payment or collaborative basis as per the needs of the particular entity.
a) An attractive drug target among coronaviruses is the main protease (Mpro, also called 3CLpro) because of its essential role in processing the polyproteins that are translated from the viral RNA. CSIR-CDRI can screen compounds against the target and also will carry out co-crystallization studies based on the particular requirements.
b) The papain-like protease (PLpro) of SARS-CoV-2 plays essential roles in virus replication and immune evasion, and represents an attractive drug target. CSIR-CDRI can screen compounds and carry out co-crystallisation studies against this target based on the particular project needs.