Introduction/Background

Clerodane diterpene, a natural compound isolated from leaves (a renewable resource) of Polyalthia longifolia (False Ashoka), is a new class of HMG-CoA reductase inhibitor.

Highlight Description

Our studies provide the first evidence that clerodane diterpene inhibits triglyceride accumulation in-vitro in adipocytes. Furthermore, clerodane diterpene ameliorates dyslipidemia and obesity like FDA approved drug (Orlistat) when given in mice. Taken together, clerodane diterpene is good candidate as a translational lead for metabolic disorders.

Importance/Unique Salient Feature

Clerodane diterpene, although belonging to a distinct chemical class, possess triglyceride lowering activity specifically targeting Indian population for treating dyslipidemia.

Patent Status

Title: A process for isolation of 16a-hydroxycleroda-3,13(14)Z-dien-15,16-olide from Polyalthia longifolia
Inventors: Koneni Venkata Sashidhara, Anju Puri & Jammikuntla Naga Rosaiah
Application Number: 0773DEL2008; Date: 26-Mar-08

Title: Method of treating dyslipidemia using naturally occurring diterpene
Inventors: Koneni Venkata Sashidhara, Anju Puri & Jammikuntla Naga Rosaiah
Application Number: US-12/323156 , Date of Filing: 25-Nov-08, Grant No. 89215417, Grant Date: 30-Dec-14