Research Interests

Research in female reproduction, infertility and reproductive disorders

Embryonic development to the blastocyst stage and endometrium differentiation to the receptive environment are essential for the establishment of the embryo uterine cross-talk that govern the initiation and progression of successful embryo implantation. Although several molecules have been identified which are involved in uterine receptivity and embryo-uterine cross talk, the molecular mechanism exerted by these molecules remains unclear as yet. Infertility is a major healthcare problem at multiple interfaces of human life. There is no robust tool of diagnosis except laparoscopic investigation as there is no reliable marker of receptivity. On the other hand, unintended pregnancy is a significant global health problem. Our laboratory is primarily involved in studies on the factors regulating early reproductive events taking place in oviduct, and the factors and mechanisms that govern the endometrial gene expression during implantation phase. The overall aim of these projects is to provide better understanding of embryonic development, embryo implantation and discovery of new receptivity markers which might be exploited as future targets for contraception. Studies will also help develop novel diagnostic approaches for infertility and strategies for management of infertility. Besides, our research area of interest also includes the understanding of the pathogenesis of endometrial disorders particularly endometrial hyperplasia and endometriosis and to develop new treatment strategies for the disease.