Research Interests

Regulatory Safety Pharmacology (Cardiovascular disorders)

Understanding the biology of vascular endothelial cells

The inner most lining of the blood vessel is comprised of Endothelial cells providing an anticoagulant barrier between the vessel wall and blood components. The endothelial cells are multitasking cells having myriad functions like participating in maintaining the vascular tone, homeostasis, immune and initiate inflammatory response, respond to physical and chemical stimuli, initiate angiogenesis and vasculogenesis. Our lab is focussed on how these endothelial cells respond to various stimuli in both normal as well as in pathophysiological conditions specifically in the cardiovascular diseases (Myocardial infarction and hypertrophy). We simulate these processes using rodent models and inhibit the disease with various in house designed pharmacological inhibitors and elucidate the molecular mechanisms involved between inhibitors and endothelial cells. Further, we are also interested in understanding the basic intercellular signalling between endothelial cells and pericytes (cells surrounding endothelial cells) in the process of angiogenesis which is essential for normal growth and diseases like cancer, ischaemia etc.