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Research Interests

Energy homeostasis is the balance between energy input and expenditure. Our health is intricately regulated by energy homeostasis and any imbalance in it may result in metabolic diseases including diabetes and cancer. The focus of our research is understanding the molecular basis of energy homeostasis and their modulation in diseases like diabetes, cancer skeletal muscle atrophy and osteoporosis.

Selected recent publications

image01Khan MP, Singh AK, Joharapurkar AA, Yadav M, Shree S, Kumar H, Gurjar A, Mishra JS, Chandra Tiwari M, Nagar GK, Kumar S, Ramachandran R, Sharan A, Jain MR, Trivedi AK, Maurya R, Godbole MM, Gayen JR, Sanyal S*, Chattopadhyay N*. 2015. Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPARγ coactivator-1α and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia. Diabetes. 64:2609-23. doi: 10.2337/db14-1611. *Co-corresponding author.
image01Khan MP, Singh AK, Singh AK, Shrivastava P, Tiwari MC, Nagar GK, Bora HK, Parameswaran V, Sanyal S, Bellare JR, Chattopadhyay N. 2015. Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate. J Bone Miner Res. 2015 Sep 22. doi: 10.1002/jbmr.2719. [Epub ahead of print]
image01Kapoor I, Kanaujiya J, Kumar Y, Thota JR, Bhatt ML, Chattopadhyay N, Sanyal S, Trivedi AK. 2015. Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. Oncotarget. 2015 Oct 25. doi: 10.18632/oncotarget.6156. [Epub ahead of print]
image01Singh AK, Joharapurkar AA, Khan MP, Mishra JS, Singh N, Yadav M, Hossain Z, Khan K, Kumar S, Dhanesha NA, Mishra DP, Maurya R, Sharma S, Jain MR, Trivedi AK, Godbole MM, Gayen JR, Chattopadhyay N, Sanyal S. 2014. Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling and improves metabolic health in a rodent model of diabetes. Diabetes 63:3530-3544.
image01Singh N, Yadav M, Singh AK, Kumar H, Dwivedi SK, Mishra JS, Gurjar A, Manhas A, Chandra S, Yadav PN, Jagavelu K, Siddiqi MI, Trivedi AK, Chattopadhyay N, Sanyal S. 2014. Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein–Coupled Receptors. Molecular Endocrinology 28:659-673.