Research Interests

Faithful segregation of chromosomes is essential for the maintenance of genome integrity. Checkpoints are the key events that ensure the faithful cell cycle progression and genome integrity. The fission yeast has been an extremely valuable system for identifying and characterizing components of cell cycle checkpoint. Primary focus of our lab is to understand the mechanistic aspect of cell cycle checkpoint using genetics and biochemical approaches. Currently the major projects going on in these directions are to understand the role of Wat1/pop3 protein during stress response and its genetic interaction with cell cycle checkpoint protein kinase Chk1. Simultaneously we are also exploring the role of heterochromatin proteins and tumor suppressor protein Drp1, in DNA damage response and their implication on cell cycle checkpoint.