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• Drug Discovery and Development

The research in my group involves the rational design and synthesis of biologically important natural and synthetic compounds of biomedical significance and development of new organic synthetic methodologies.

  • Natural Product Chemistry

Another area of active interest includes natural product chemistry. Natural products represent the richest source of novel molecular scaffolds and chemistry. It is hard to predict in advance, the details of how a natural product will interact with the myriad of targets that we now know drive fundamental biological processes. Natural product isolation by activity directed fractionation and structural elucidation remain an important area of research in our lab.

image01  Selected publications:

  • Sashidhara, K. V.; Palnati, G. R.; Singh, L. R.; Upadhyay, A.; Avula, S. R.; Kumar, A.; Kant, R. Molecular iodine catalysed one-pot synthesis of chromeno[4,3-b]quinolin-6-ones under microwave irradiation. Green Chemistry 2015, 17, 3766-3770

  • Sashidhara, K. V.; Rao, K. B.; Kushwaha, P.; Modukuri, R. K.; Singh, P.; Soni, I.; Shukla, P. K.; Chopra, S.; Pasupuleti, M. Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. ACS Medicinal Chemistry Letters 2015, 6, 809-813. (Front cover page article)

  • Beg, M.; Shankar, K.; Varshney, S.; Rajan, S.; Singh, S. P.; Jagdale, P.; Puri, A.; Chaudhari, S. P.; Sashidhara, K. V.; Gaikwad, A. N. A clerodane diterpene inhibit adipogenesis by cell cycle arrest and ameliorate obesity in C57BL/6 mice. Molecular and Cellular Endocrinology 2015, 399, 373-385

  • Sashidhara, K. V.; Modukuri, R. K.; Jadiya, P.; Rao, K. B.; Sharma, T.; Haque, R.; Singh, D. K.; Banerjee, D.; Siddiqi, M. I.; Nazir, A. Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson's Disease. ACS Medicinal Chemistry Letters 2014, 5, 1099-1103. (Front cover page article)

  • Sashidhara, K. V.; Kumar, M.; Khedgikar, V.; Kushwaha, P.; Modukuri, R. K.; Kumar, A.; Gautam, J.; Singh, D.; Sridhar, B.; Trivedi, R. Discovery of Coumarin-Dihydropyridine Hybrids as Bone Anabolic Agents. Journal of Medicinal Chemistry 2013, 56, 109-122.

  • Sashidhara, K. V.; Kumar, M.; Sonkar, R.; Singh, B. S.; Khanna, A. K.; Bhatia, G. Indole-Based Fibrates as Potential Hypolipidemic and Antiobesity Agents. Journal of Medicinal Chemistry 2012, 55, 2769-2779.

  • Sashidhara, K. V.; Kumar, A.; Agarwal, S.; Kumar, M.; Kumar, B.; Sridhar, B. A Simple and Efficient Access to New Functionalized 4-Phenacylideneflavenes. Advanced Synthesis & Catalysis 2012, 354, 1129-1140.