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Research Interests

Insulin resistance and type 2 diabetes

Insulin resistance is a major defect underlying the development of type 2 diabetes and is a central component of the metabolic syndrome. It is characterized by complex interactions among genetic determinants, nutritional factors, and lifestyle. Multiple biochemical, metabolic, and signal transduction pathways contribute to insulin resistance. As the incidence of obesity and insulin resistance continues to rise in adolescents and adults at staggering levels, new approaches to tackling this world-wide epidemic are warranted. The overall focus of our laboratory is to explore the new mechanisms involved in induction of insulin resistance, and to identify and develop new molecules to counteract insulin resistance for the treatment of type 2 diabetes. We are investigating the role of innate immune components in inflammation-mediated insulin resistance. Simultaneously we are exploring the input of dietary fructose, with specific reference to extra hepatic metabolism, in induction of insulin resistance. At the same time we are involved in the discovery, development and validation of novel antidiabetic agents from natural as well as synthetic sources, using various in vitro and in vivo model systems.