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Research Interests

Protein-Protein interactions (PPI) are instrumental to most biological processes-from intercellular communication to programmed cell death, and therefore represent a large andimportant class of targets for human therapeutics. Our laboratorybasically focuses ontoidentify novel host proteins interacting with HIV-1 Nef and understand the cellular pathways regulated by these interactions causing pathogenesis. The viral-host protein interactions are becoming novel targets for developing anti-viral therapeutics. We screen novel synthetic compounds or natural products active against HIV-1-Reverse Transcriptase (RT) enzyme. Our lab is also involved in developing in vitro and in vivo models for evaluating immuno-toxicity of natural and synthetic compounds.