Research Interests

1. Understanding Mycobacterium tuberculosis persistence in search of robust drug targets:

Mycobacterium tuberculosis is a successful pathogen primarily because of its remarkable ability to persist in an immunocompetent host. Persisters being phenotypically drug tolerant are difficult to eradicate. With the ultimate aim of fighting the persisters along with actively replicating forms of the bacilli, we a) try to understand the mechanisms ofM. tuberculosis persistence, b) develop tools to detect persisters and c) validate in vitro models of persisters

2. Role of non-immune cells in Mycobacterium tuberculosis infection:

There is emerging evidence of the role of host cells not belonging to the immune system in M. tuberculosis persistence or immunomodulation during infection process. We have contributed to this area of TB research by our studies on interactions of M. tuberculosis with the adipocytes and lung fibroblasts.

3. Discovery of new anti-tubercular agents:

New TB drugs with novel mode of action are continuously in demand owing to the emergence of drug resistance. We screen novel molecules designed against the clinically validated target mycobacterial ATP synthase. Efforts are on to develop new target-based screening assays.