Research Interests


Pharmacokinetics is described as what the body does to a drug. It involves studying drugs’ absorption, distribution, metabolism and elimination (ADME) in various preclinical and clinical species. With the advent of three ‘R’ principle (replacement, reduction and refinement) for the ethical use of animals in testing, development and validation of a sensitive and selective bioanalytical method in plasma, blood, serum and dried blood spots, has become an integral part of the routine pharmacokinetic analysis. The developed bioanalytical method is applied for the in vitro and in vivo pharmacokinetic studies of various NCE’s and drug candidates in different phases of clinical trials. Apart from these, software based pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation techniques are gaining a significant importance in the current scenario of drug discovery and development. PK/PD modelling and simulation can be used as an ‘applied science’ tool to provide answers on efficacy and safety of new drugs faster and at a lower cost.