Research Interests


Introduction

The current world population of 7.3 billion is expected to rise to 8.5 billion by 2030, 9.7 billion by 2050 and 11.2 billion by 2100. Thirty seven percent of world’s population resides in China and India. According to the United Nations, by 2028 India is estimated to have 1.454 billion people against 1.453 billion in China. Though India’s fertility rates have dropped from 3.6 in 1991 to 2.3 in 2013, China’s fertility rates have dropped to much lower levels. On the other hand, India is much more densely populated (382 people per sq km) than China (141 people per sq km), which puts a lot of pressure on our natural resources. Even after achieving replacement level fertility rate of 2.1, the population growth in India would be driven by the “population momentum”, which is due to increased life span of people resulting in several generations living together. On the other hand, curable sexually transmitted infections, which increase the risk of contracting viral STDs and HIV, are a major health problem in developing countries like India. Hence reversible contraceptive methods aimed at spacing childbirth and protecting against some common STDs become very important.

The research of our group focuses on the following:
  • The search of novel targets for contraception and reproductive health by studying:

    ○ Molecular mechanisms associated with motility initiation of the sperm during ejaculation
    ○Thermal regulation of testicular spermatogenesis in mammals
    ○Identification of common targets on sperm and some common STD pathogens like Trichomonas vaginalis that are vulnerable to designed chemical interference for prophylactic contraception
    ○ Association of Trichomoniasis with pathogenesis of prostate cancer
    ○ The epigenetic regulation of hormonal sensitivity of prostate cancer
    ○ Management of benign prostatic hyperplasia

  • Design, synthesis and evaluation of novel chemical entities with sperm immobilizing (spermicidal/spermiostatic) and anti-Trichomonas (Trichomonas vaginalis causing Trichomoniasis, which is globally the most prevalent STD that increases susceptibility to HIV) agents.

  • Mimicking the natural safe period of menstrual cycle for designing a novel and safe method of contraception

  • The study of sperm energetics