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Research Interests

Reproductive Endocrinology

Identification and development of new ‘novel’ male and female anti-fertility agents/ aphrodisiac agents, and studies on molecular mechanism of action of CDRI Compounds/plant extracts.

To investigate male antifertility potential of indigenous plant products/CDRI Compounds alone or in combinations.
To study the mechanism of action on semen/sperm characteristics, viz. sperm morphology, count, motility, capacitating and fertilizing ability, and sperm marker enzymes and genes.
Establishment of mode of action of bioactive molecules on testicular spermatogenesis, receptors, growth factors, apoptosis and its hormonal profile.
To investigate aphrodisiac activity of indigenous plants extracts and studies related to its mechanism of action on fertility regulation, sexual behavior, erectile dysfunction and pro-fertility activity of bioactive molecules.
Studies on female contraceptive potential of indigenous plants extract alone or in combinations.
Identification of post-coital efficacy, estrogenicity, antiestrogenicity, progestational and antiprogestational activity, androgenic/antiandrogenic activity and anti-gonadotrophic activity.
To study steroidogenic pathway, ‘marker’ enzymes- 17β HSDs, Aromatase, 3 β-HSD, E2 and P levels, ER and PR, and E2-regulated uterine gene expression during pre-implantation, implantation and post-implantation period and decidualization.

Studies on molecular mechanism of action of Centchroman and CDRI 85/287 during implantation and decidualization processes.

To investigate the endometrial gene expression profile during pre-implantation, implantation and post-implantation period in comparison to treated animals in order to find potential predictive markers of uterine receptivity and to identify the molecular mechanisms of implantation/antiimplantation.
To study the histo-morphometric analysis, localization/expression of estradiol-dehydrogenase (17ßHSD2), estrone dehydrogenase (17ßHSD1), genomic DNA analysis and apoptosis studies in uterus during implantation and decidualization under the influence of centchroman and CDRI-85/287.

Studies on cadmium induced genetic (Microsatelites) instability, oxidative toxicity, chromosomal abnormalities and Y chromosome microdeletions in rats: Protective effects of flavonoids and Vitamins.

To study effects on body and organ weights, testicular spermatogenesis, sperm counts and morphology.
To study chromosomal aberrations, microsatellite instability and oxidative damage and apoptosis in testis.
To study protective effects of flavonoids and vitamins.
This study will highlight the possible molecular mechanisms behind the therapeutic and protective role of flavonoids in ameliorating testicular toxicity, semen quality, genetic abnormalities in CdCl2 and other drugs intoxicated rats.